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The amount of melanin in the skin was measured at the 3 following locations representing various degrees of sun exposure for a total of 3 times each and the values were averaged: On the cheek of the subject, directly under the pupil on the zygomatic arch, on the forehead of the subject, midline about an inch above eyebrows, and on the upper, outer, right buttock (‘hip’). The ABPM monitor was worn continuously for a minimum of 24 h at 3 timepoints throughout the study: baseline, approximately mid-way through dosing duration, and at the end of dosing. Measurements were taken prior to dosing, weekly during dosing, and at follow-up visits. Picard 2.4.2 for mac pro. The ABPM device was programmed to take readings every 20 min during the 24-hour monitoring period.Quantitative skin color measurements: Quantitative skin measurements were performed with a spectrophotometric device, the Mexameter-18, Courage + Khazaka Electronic, GmbH, Cologne, Germany.

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